Energy-optimal electrical-stimulation pulses shaped by the Least-Action Principle

PLoS One. 2014 Mar 13;9(3):e90480. doi: 10.1371/journal.pone.0090480. eCollection 2014.

Abstract

Electrical stimulation (ES) devices interact with excitable neural tissue toward eliciting action potentials (AP's) by specific current patterns. Low-energy ES prevents tissue damage and loss of specificity. Hence to identify optimal stimulation-current waveforms is a relevant problem, whose solution may have significant impact on the related medical (e.g. minimized side-effects) and engineering (e.g. maximized battery-life) efficiency. This has typically been addressed by simulation (of a given excitable-tissue model) and iterative numerical optimization with hard discontinuous constraints--e.g. AP's are all-or-none phenomena. Such approach is computationally expensive, while the solution is uncertain--e.g. may converge to local-only energy-minima and be model-specific. We exploit the Least-Action Principle (LAP). First, we derive in closed form the general template of the membrane-potential's temporal trajectory, which minimizes the ES energy integral over time and over any space-clamp ionic current model. From the given model we then obtain the specific energy-efficient current waveform, which is demonstrated to be globally optimal. The solution is model-independent by construction. We illustrate the approach by a broad set of example situations with some of the most popular ionic current models from the literature. The proposed approach may result in the significant improvement of solution efficiency: cumbersome and uncertain iteration is replaced by a single quadrature of a system of ordinary differential equations. The approach is further validated by enabling a general comparison to the conventional simulation and optimization results from the literature, including one of our own, based on finite-horizon optimal control. Applying the LAP also resulted in a number of general ES optimality principles. One such succinct observation is that ES with long pulse durations is much more sensitive to the pulse's shape whereas a rectangular pulse is most frequently optimal for short pulse durations.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Algorithms
  • Animals
  • Axons / physiology
  • Biomedical Engineering / methods*
  • Computer Simulation
  • Electric Stimulation
  • Equipment Design
  • Humans
  • Mathematics
  • Models, Theoretical
  • Myelin Sheath / chemistry
  • Peripheral Nervous System / physiology
  • Temperature

Grants and funding

The Fonds de recherche du Quebec - Nature et technologies and the Natural Sciences and Engineering Research Council of Canada provided funding for this work. S.D. was supported by the Vienna Science and Technology Fund (WWTF), Proj.Nr. LS11-057. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.