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J Infect Dis. 2014 Aug 1;210(3):441-7. doi: 10.1093/infdis/jiu116. Epub 2014 Mar 12.

High-risk oral human papillomavirus load in the US population, National Health and Nutrition Examination Survey 2009-2010.

Author information

1
Division of Cancer Epidemiology and Genetics, National Cancer Institute, National institutes of Health, Rockville, Maryland;
2
The Ohio State University, Columbus.

Abstract

We investigated the association of demographic and behavioral factors with oral human papillomavirus (HPV) load for 18 high-risk types among 211 individuals with prevalent high-risk HPV within the National Health and Nutrition Examination Survey 2009-2010. Factors independently associated with HPV load above the median included older age (odds ratio, 1.04 per year increase [95% confidence interval, 1.01-1.07]; P = .004) and intensity of current smoking (P for trend <.001). A marginally greater percentage of men than women had an HPV load above the median (55.7% vs 32.8%; P = .069), and HPV load increased marginally with increasing alcohol use (P for trend = .062). In conclusion, older age and current smoking are associated with a high oral load of high-risk HPV types among individuals with a prevalent infection.

KEYWORDS:

Human papillomavirus (HPV); NHANES; oral; oropharynx; smoking; viral load

PMID:
24625808
PMCID:
PMC4110460
DOI:
10.1093/infdis/jiu116
[Indexed for MEDLINE]
Free PMC Article

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