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Curr Med Res Opin. 2014 Jul;30(7):1353-6. doi: 10.1185/03007995.2014.901942. Epub 2014 Mar 26.

Assessing age and gender in studies of breakthrough pain medications.

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1
La Maddalena Cancer Center , Palermo , Italy.

Abstract

OBJECTIVE:

The present review was performed to identify possible differences observed between adults and elderly patients and between males and females in randomized clinical trials of breakthrough pain (BTP).

METHODS:

A systematic search of the existing literature from 1998 to September 2013 was performed. Randomized clinical trials reporting data on older patients were selected.

RESULTS:

Sixteen comparative studies were selected. The age range of inclusion criteria patients was mainly between 18-80 or ≥18 years. In some cases this data was unreported. The mean age of patients was 48-64 years, but information regarding the number of elderly patients was present in three studies only. Gender distribution was more or less 50%:50%. No subgroup analysis of efficacy or adverse effects of BTP medications for age and gender was reported.

CONCLUSION:

There is a need for more information regarding the use of opioids for BTP according to age and gender.

KEYWORDS:

Age; Breakthrough pain; Cancer pain; Fentanyl; Gender

PMID:
24625119
DOI:
10.1185/03007995.2014.901942
[Indexed for MEDLINE]
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