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Eur J Immunol. 1988 Nov;18(11):1797-801.

Excessive production of interleukin 6/B cell stimulatory factor-2 in rheumatoid arthritis.

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1
Division of Immunology, Osaka University, Japan.

Abstract

High levels of interleukin 6 (IL 6/B cell stimulatory factor-2) were detected in synovial fluids from the joints of patients with active rheumatoid arthritis (RA). The cells found in freshly isolated synovial fluid constitutively expressed IL 6 mRNA. The synovial tissues obtained by joint biopsy were also found to produce IL 6 in vitro. Immunohistochemical analysis demonstrated that CD2+ T cells as well as CD20+ blastoid B cells in the synovial tissues produce IL 6. The data indicate that IL 6 is generated constitutively in RA and its overproduction may explain the local as well as the generalized symptoms of RA, since IL 6 can function as B cell growth and differentiation factor as well as hepatocyte-stimulating factor.

PMID:
2462501
DOI:
10.1002/eji.1830181122
[Indexed for MEDLINE]
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