A simple and efficient synthesis of substituted 2,2'-bithiophene and 2,2':5',2″-terthiophene

Org Lett. 2014 Apr 4;16(7):1833-5. doi: 10.1021/ol500356w. Epub 2014 Mar 13.

Abstract

A simple and efficient approach is developed for the synthesis of substituted 2,2'-bithiophene- and 2,2':5',2″-terthiophene-5-carboxylic acids and esters which is based on thiophene ring closure in the Fiesselmann reaction. Using this method, derivatives containing a long alkyl chain with or without an end functional group or an aryl substituent can be conveniently prepared.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Carboxylic Acids / chemical synthesis*
  • Carboxylic Acids / chemistry
  • Esters
  • Ketones / chemistry
  • Molecular Structure
  • Thiophenes / chemical synthesis*
  • Thiophenes / chemistry

Substances

  • Carboxylic Acids
  • Esters
  • Ketones
  • Thiophenes