Format

Send to

Choose Destination
Front Cell Infect Microbiol. 2014 Mar 4;4:27. doi: 10.3389/fcimb.2014.00027. eCollection 2014.

What's in a word: the use, misuse, and abuse of the word "persistence" in Chlamydia biology.

Author information

1
Department of Microbial Pathogenesis, School of Dentistry, University of Maryland Baltimore, MD, USA.

Abstract

The word persistence was used by Chlamydia researchers almost as soon as Chlamydia research was born to reflect the propensity of chlamydiae to cause inapparent infection in their hosts, from birds to humans. More recently, the term persistence has been used, misused, and sometimes abused amidst in vitro and in vivo studies that aim to mimick the ability of chlamydiae to emerge from the presumed inapparent state into clinically detectable infection and disease. Here, I have attempted to provide a global perspective on the state of research on chlamydial persistence, revisiting old observations that may warrant a new look, critically evaluating more recent observations and their shortcomings, and including recent developments that may help redefine chlamydiae as pathogens-or not-of both animals and humans.

KEYWORDS:

Chlamydia; aberrant body; commensalism; persistence; recurrence

PMID:
24624366
PMCID:
PMC3940941
DOI:
10.3389/fcimb.2014.00027
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for PubMed Central
Loading ...
Support Center