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J Thorac Dis. 2014 Mar;6(3):221-9. doi: 10.3978/j.issn.2072-1439.2013.11.12.

Efficacy and safety of moxifloxacin in acute exacerbations of chronic bronchitis and COPD: a systematic review and meta-analysis.

Author information

1
1 Department of Respiratory disease, The First Affiliated Hospital, Fujian Medical University, Fuzhou 350005, China ; 2 Laboratory of Respiratory Disease of Fujian Medical University, Fuzhou 350005, China ; 3 Department of Neurology, Fujian Geriatric Hospital, Fuzhou 350003, China ; 4 Department of Respiratory Medicine, Huadong Hospital, Shanghai Medical School of Fudan University, Shanghai 200040, China ; 5 Department of Pulmonary Medicine, Zhongshan Hospital, Shanghai Medical School of Fudan University, Shanghai 200032, China.

Abstract

PURPOSE:

To evaluate the efficacy and safety of moxifloxacin in acute exacerbations of chronic bronchitis (AECB) and chronic obstructive pulmonary disease (AECOPD).

METHODS:

We searched PubMed, EMBASE, and the Web of Science for relevant studies. Two reviewers extracted data and reviewed the quality of the studies independently. The primary outcome was clinical success at early follow-up. Study-level data were pooled using a random-effects model when I(2) was >50% or a fixed-effects model when I(2) was <50%.

RESULTS:

Eleven randomized controlled studies were considered. There was no difference between moxifloxacin and comparator agents with regard to treatment success in intention-to-treat (ITT) [odds ratio (OR) =1.18, 95% confidence interval (CI) 0.98-1.42], clinically evaluable (CE) (OR 1.13, 95% CI, 0.93-1.37) patients, or adverse effects in general (OR 1.00, 95% CI, 0.86-1.17). Moxifloxacin was associated with better microbiological success (OR 1.45; 95% CI, 1.14-1.85).

CONCLUSIONS:

Moxifloxacin was as clinically equivalent and bacteriologically superior to the antibiotic regimens routinely used in patients with AECB and AECOPD. Moxifloxacin therapy may be a promising and safe alternative to empirical treatment for AECB and AECOPD.

KEYWORDS:

Moxifloxacin; chronic bronchitis; chronic obstructive pulmonary disease (COPD); meta-analysis; systematic review

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