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Adv Healthc Mater. 2014 Sep;3(9):1392-7. doi: 10.1002/adhm.201400054. Epub 2014 Mar 13.

Lipid-like nanomaterials for simultaneous gene expression and silencing in vivo.

Author information

1
David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA; Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA; Department of Anesthesiology, Children's Hospital Boston, 300 Longwood Avenue, Boston, MA, 02115, USA.

Abstract

New lipid-like nanomaterials are developed to simultaneously regulate expression of multiple genes. Self-assembled nanoparticles are capable of efficiently encapsulating pDNA and siRNA. These nanoparticles are shown to induce simultaneous gene expression and silencing both in vitro and in vivo.

KEYWORDS:

gene expression; gene silencing; lipid-like nanomaterials; plasmid DNA; siRNA

PMID:
24623658
PMCID:
PMC4160381
DOI:
10.1002/adhm.201400054
[Indexed for MEDLINE]
Free PMC Article

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