Abstract
We performed the reaction of vitamin B12 with N,N-dimethylformamide dimethyl acetal for primary amide activation, and added MeOH as a nucleophile, to afford cobalester, the first amphiphilic cobalamin derivative. The unique combination of redox properties and solubility represents an asset for its use as a catalyst in C-C bond forming reactions.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Catalysis
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Cobamides / analysis
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Cobamides / chemistry
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Cobamides / metabolism
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Dimethylformamide / analogs & derivatives
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Dimethylformamide / analysis
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Dimethylformamide / chemistry
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Dimethylformamide / metabolism
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Oxidation-Reduction
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Surface-Active Agents / analysis
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Surface-Active Agents / chemistry*
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Surface-Active Agents / metabolism
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Vitamin B 12 / analysis
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Vitamin B 12 / chemistry*
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Vitamin B 12 / metabolism
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X-Ray Diffraction
Substances
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Cobamides
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Surface-Active Agents
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cobinamide
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dimethylformamide-dimethylacetal
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Dimethylformamide
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Vitamin B 12