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Lancet Diabetes Endocrinol. 2014 Jan;2(1):56-64. doi: 10.1016/S2213-8587(13)70112-8. Epub 2013 Dec 3.

Diabetes: a 21st century challenge.

Author information

1
Baker IDI Heart and Diabetes Institute, Melbourne, VIC, Australia. Electronic address: paul.zimmet@bakeridi.edu.au.
2
Baker IDI Heart and Diabetes Institute, Melbourne, VIC, Australia.
3
Michigan Center for Diabetes Translational Research, University of Michigan, Ann Arbor, MI, USA.

Abstract

The number of people with diabetes worldwide has more than doubled during the past 20 years. One of the most worrying features of this rapid increase is the emergence of type 2 diabetes in children, adolescents, and young adults. Although the role of traditional risk factors for type 2 diabetes (eg, genetic, lifestyle, and behavioural risk factors) has been given attention, recent research has focused on identifying the contributions of epigenetic mechanisms and the effect of the intrauterine environment. Epidemiological data predict an inexorable and unsustainable increase in global health expenditure attributable to diabetes, so disease prevention should be given high priority. An integrated approach is needed to prevent type 2 diabetes, taking into account its many origins and heterogeneity. Thus, research needs to be directed at improved understanding of the potential role of determinants such as the maternal environment and other early life factors, as well as changing trends in global demography, to help shape disease prevention programmes.

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PMID:
24622669
DOI:
10.1016/S2213-8587(13)70112-8
[Indexed for MEDLINE]
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