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Lancet Diabetes Endocrinol. 2013 Nov;1(3):250-8. doi: 10.1016/S2213-8587(13)70069-X. Epub 2013 Oct 18.

The role of thyroid hormone and brown adipose tissue in energy homoeostasis.

Author information

1
Division of Endocrinology, Diabetes and Metabolism, University of Miami Miller School of Medicine, Miami, FL, USA. Electronic address: abianco@deiodinase.org.
2
Division of Endocrinology, Diabetes and Metabolism, University of Miami Miller School of Medicine, Miami, FL, USA.

Abstract

The presence of brown adipose tissue (BAT) in adults has become increasingly well defined as a result of functional imaging studies of thermogenically active BAT. Findings from these studies have created a surge of scientific interest in BAT, because it represents a potential therapeutic target for obesity--a condition with profound health consequences and few successful therapies. BAT contributes to overall energy expenditure in small mammals and neonates through adaptive thermogenesis. Thyroid-hormone signalling, particularly through induction of type II deiodinase, has a central role in brown adipogenesis in vitro and BAT development in mouse embryos. Additionally, because of high intracellular expression of type II deiodinase, adult BAT has enhanced thyroid-hormone signalling with several thyroid-hormone-dependent thermogenic pathways, including expression of the genes Ppargc1a and Ucp1. BAT thermogenesis explains the essential part played by thyroid hormone in energy homoeostasis and adaptation to cold. Stimulation of BAT in adults, specifically through thyroid-hormone-mediated pathways, is a promising therapeutic target for obesity.

PMID:
24622373
PMCID:
PMC4976626
DOI:
10.1016/S2213-8587(13)70069-X
[Indexed for MEDLINE]
Free PMC Article
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