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Chem Commun (Camb). 2014 Apr 21;50(31):4096-8. doi: 10.1039/c3cc49198f.

Benzoselenadiazole-based responsive long-lifetime photoluminescent probes for protein kinases.

Author information

1
Institute of Chemistry, University of Tartu, 14A Ravila St., 50411 Tartu, Estonia. asko.uri@ut.ee.

Abstract

Benzoselenadiazole-containing inhibitors of protein kinases were constructed and their capability to emit phosphorescence in the kinase-bound state was established. Labelling of the inhibitors with a red fluorescent dye led to sensitive responsive photoluminescent probes for protein kinase CK2 that emitted red light with a long (microsecond-scale) decay time upon excitation of the probes with a pulse of near-UV light.

PMID:
24619026
DOI:
10.1039/c3cc49198f
[Indexed for MEDLINE]

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