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Org Biomol Chem. 2014 Apr 28;12(16):2514-8. doi: 10.1039/c3ob42535e.

A direct access to bioactive fused N-heterocyclic acetic acid derivatives.

Author information

1
Dr Reddy's Institute of Life Sciences, University of Hyderabad Campus, Gachibowli, Hyderabad 500 046, India. manojitpal@rediffmail.com.

Abstract

A Cu-catalyzed new sequence involving the Ullmann type intermolecular C-C followed by an intramolecular C-N coupling and then intramolecular aza-Michael type addition (and oxidation) in a single pot afforded various fused N-heterocyclic acetic acid derivatives as inhibitors of PDE4.

PMID:
24618745
DOI:
10.1039/c3ob42535e
[Indexed for MEDLINE]
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