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Ann Oncol. 2014 Jul;25(7):1320-7. doi: 10.1093/annonc/mdu119. Epub 2014 Mar 11.

Age-dependent differences in borderline ovarian tumours (BOT) regarding clinical characteristics and outcome: results from a sub-analysis of the Arbeitsgemeinschaft Gynaekologische Onkologie (AGO) ROBOT study.

Author information

1
Department of Gynaecology and Gynaecologic Oncology.
2
Department of Gynaecology and Gynaecologic Oncology s.mahner@uke.uni-hamburg.de.
3
Department of Medical Biometry and Epidemiology, Universitätsklinikum Hamburg-Eppendorf, Hamburg.
4
Department of Coordinating Center for Clinical Trials, Marburg.
5
Department of Gynaecology and Gynaecologic Oncology, Dr Horst Schmidt Klinik GmbH, Wiesbaden.
6
Department of Gynaecolgy and Obstetrics, Universitätsklinikum Ulm, Ulm.
7
Department of Gynaecolgy, Charité, Campus Virchow Klinikum, Berlin.
8
Department of Obstetrics and Gynaecolgy, Klinikum Rechts der Isar der Technischen Universität, Munich.
9
Department of Obstetrics and Gynaecolgy, Klinikum der Universität München, Munich.
10
Department of Gynaecolgy and Obstetrics, Universitätsklinikum Schleswig-Holstein, Kiel.
11
Department of Gynaecolgy and Obstetrics, Universitätsklinikum Tübingen, Tuebingen.
12
Department of Gynaecolgy and Obstetrics, Evangelisches Krankenhaus, Duesseldorf.
13
Department of Gynaecolgy and Obstetrics, Medizinische Hochschule Hannover, Hannover.
14
Department of Gynaecolgy and Obstetrics, Klinikum der J.W. Goethe-Universität, Frankfurt/M Department of Gynaecolgy and Obstetrics, Universitätsklinikum Schleswig-Holstein, Luebeck.
15
Department of Obstetrics and Gynaecolgy, Universitätsklinikum Freiburg, Freiburg.
16
Department of Gynaecolgy and Obstetrics, Universitätsklinikum Halle/S., Halle/S.
17
Department of Gynaecolgy and Obstetrics, Georg-August-Universität Göttingen, Goettingen.
18
Clinic of Gynaecolgy and Obstetrics, Universitätsklinikum Essen, Essen Department of Gynaecolgy and Obstetrics, Universitätsklinikum Carl Gustav Carus, Dresden.
19
Department of Gynaecolgy, Endocrinology and Oncology, Universitätsklinikum Gießen u. Marburg GmbH, Marburg.
20
Department of Obstetrics and Gynaecolgy, Rheinische Friedrich-Wilhelms-Universität, Bonn.
21
Department of Gynaecolgy and Obstetrics, Universitätsklinikum Carl Gustav Carus, Dresden.
22
Department of Gynaecolgy and Obstetrics, Universitätsklinikum Magdeburg, Magdeburg.
23
Department of Gynaecolgy and Obstetrics, Sana-Klinikum Remscheid, Remscheid.
24
Department of Gynaecolgy and Obstetrics, Städtisches Klinikum Solingen gGmbH, Solingen Zentrum für Gynäkologische Onkologie, Kiel.
25
GYNAEKOLOGICUM Bremen, Bremen.
26
Department of Obstetrics and Gynaecolgy, Universitätsklinikum Gießen, Gießen.
27
Department of Gynaecology and Obstetrics, Elblandkliniken Meißen-Radebeul GmbH & Co. KG, Radebeul.
28
Institute of Pathology, Referenzzentrum für Gynäkopathologie, Mannheim.
29
Department of Gynaecolgy and Obstetrics, Universitätsklinikum Halle/S., Halle/S Institute of Pathology, Trier-Dueren-Duesseldorf, Dueren.
30
Department of Gynaecolgy and Gynaecolgic Oncology, Kliniken Essen-Mitte, Essen, Germany.

Abstract

BACKGROUND:

Approximately one-third of all borderline ovarian tumours (BOT) are diagnosed in patients with child-bearing potential. Detailed information regarding their specific characteristics and prognostic factors is limited.

METHODS:

Clinical parameters of BOT patients treated between 1998 and 2008 in 24 German centres were retrospectively investigated. Central pathology review and prospective follow-up were carried out. Patients <40 versus ≥40 years were analysed separately and then compared regarding clinico-pathological variables and prognosis.

RESULTS:

A total of 950 BOT patients with a median age of 49.1 (14.1-91.5) years were analysed [280 patients <40 years (29.5%), 670 patients ≥40 years (70.5%)]. Fertility-preserving surgery was carried out in 53.2% (149 of 280) of patients <40 years with preservation of the primarily affected ovary in 32 of these 149 cases (21.5%). Recurrence was significantly more frequent in patients <40 years (19.0% versus 10.1% 5-year recurrence rate, P < 0.001), usually in ovarian tissue, whereas disease-specific overall survival did not differ between the subgroups. In case of recurrent disease, malignant transformation was less frequent in younger than in older patients (12.0% versus 66.7%, P < 0.001), mostly presenting as invasive peritoneal carcinomatosis. Multivariate analysis for patients <40 years identified advanced International Federation of Gynecology and Obstetrics (FIGO) stage and fertility-sparing approach as independent prognostic factors negatively affecting progression-free survival (PFS) while, for patients ≥40 years, higher FIGO stage and incomplete staging was associated with impaired PFS.

CONCLUSIONS:

Despite favourable survival, young BOT patients with child-bearing potential are at higher risk for disease recurrence. However, relapses usually remain BOT in the preserved ovaries as opposed to older patients being at higher risk for malignant transformation in peritoneal or distant localisation. Therefore, fertility-sparing approach can be justified for younger patients after thorough consultation.

KEYWORDS:

borderline ovarian tumour; fertility preservation; malignant transformation; recurrence; surgical treatment

PMID:
24618151
DOI:
10.1093/annonc/mdu119
[Indexed for MEDLINE]
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