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Acta Obstet Gynecol Scand. 2014 May;93(5):490-6. doi: 10.1111/aogs.12377.

Improving reproductive long-term prognosis for women with a first ectopic pregnancy. A national controlled follow-up study.

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1
Department of Gynecology, Rigshospitalet University Hospital, University of Copenhagen, Copenhagen, Denmark.

Abstract

OBJECTIVE:

To describe developments in reproductive long-term prognosis in women with a first ectopic pregnancy as compared with two control cohorts.

DESIGN:

Controlled cohort study.

SETTING:

Data were collected from four national Danish registries.

POPULATION:

All Danish women of reproductive age (15-49 years) through the period 1977-2009 and all reproductive outcomes in these women.

METHODS:

Data were collected from four national Danish registries. Three cohorts of women with a first recorded ectopic pregnancy during the periods 1980-84, 1985-89, and 1990-94, were compared with age-matched controls with a first miscarriage and a first induced abortion and followed for 15 years for all further pregnancy outcomes.

MAIN OUTCOME MEASURES:

Pregnancy outcomes included deliveries, miscarriages, induced abortions and ectopic pregnancies.

RESULTS:

The birth rate for women with a first ectopic pregnancy increased significantly through the three cohorts from 85 to 122 deliveries/100 women during the follow-up period. The risk of miscarriages also increased over time, whereas the risk of further ectopic pregnancies remained unchanged at 22-24 events/100 women. Compared to women with a first miscarriage, the rate ratio for deliveries increased from 0.59 (95% CI 0.56-0.63) to 0.71 (95% CI 0.68-0.75) over the time covering the three cohorts.

CONCLUSION:

The long-term delivery rate among women with a first ectopic pregnancy has improved significantly over time.

KEYWORDS:

Ectopic pregnancy; delivery rate; development in reproductive prognosis; early pregnancy complications; fertility

PMID:
24617850
DOI:
10.1111/aogs.12377
[Indexed for MEDLINE]
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