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Front Cell Infect Microbiol. 2014 Feb 28;4:28. doi: 10.3389/fcimb.2014.00028. eCollection 2014.

The gut microbiota in mouse models of inflammatory bowel disease.

Author information

1
Molecular and Cellular Biology Laboratory, Division of Basic Sciences, University of Crete Medical School Heraklion, Greece ; Laboratory of Translational Medicine and Experimental Therapeutics, University of Crete Medical School Heraklion, Greece.
2
Department of Clinical Chemistry, University of Crete Medical School Heraklion, Greece.
3
Molecular and Cellular Biology Laboratory, Division of Basic Sciences, University of Crete Medical School Heraklion, Greece ; Laboratory of Translational Medicine and Experimental Therapeutics, University of Crete Medical School Heraklion, Greece ; Laboratory of Cancer Biology, Institute of Molecular Biology and Biotechnology-FORTH Heraklion, Greece.

Abstract

The intestine and the intestinal immune system have evolved through a symbiotic homeostasis under which a highly diverse microbial flora is maintained in the gastrointestinal tract while pathogenic bacteria are recognized and eliminated. Disruption of the balance between the immune system and the gut microbiota results in the development of multiple pathologies in humans. Inflammatory bowel diseases (IBD) have been associated with alterations in the composition of intestinal flora but whether these changes are causal or result of inflammation is still under dispute. Various chemical and genetic models of IBD have been developed and utilized to elucidate the complex relationship between intestinal epithelium, immune system and the gut microbiota. In this review we describe some of the most commonly used mouse models of colitis and Crohn's disease (CD) and summarize the current knowledge of how changes in microbiota composition may affect intestinal disease pathogenesis. The pursuit of gut-microbiota interactions will no doubt continue to provide invaluable insight into the complex biology of IBD.

KEYWORDS:

Crohn's disease; IBD; colitis; microbiota; mouse models

PMID:
24616886
PMCID:
PMC3937555
DOI:
10.3389/fcimb.2014.00028
[Indexed for MEDLINE]
Free PMC Article
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