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Bacteriophage. 2014 Jan 1;4(1):e28281. Epub 2014 Feb 21.

Molecular architecture of tailed double-stranded DNA phages.

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Department of Biological Sciences; Purdue University; West Lafayette, IN USA.


The tailed double-stranded DNA bacteriophages, or Caudovirales, constitute ~96% of all the known phages. Although these phages come in a great variety of sizes and morphology, their virions are mainly constructed of similar molecular building blocks via similar assembly pathways. Here we review the structure of tailed double-stranded DNA bacteriophages at a molecular level, emphasizing the structural similarity and common evolutionary origin of proteins that constitute these virions.


Caudovirales; bacteriophage structure; phage proteins; phage tails; tailed double-stranded DNA bacteriophages; virus capsids; virus structure

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