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Genet Mol Res. 2014 Jan 24;13(4):9244-52. doi: 10.4238/2014.January.24.5.

Effects of rehabilitation management on gastric emptying function in older adults with diabetes.

Author information

1
Office of the Director and Department of Gastroenterology, Huadong Hospital Affiliated to Fudan University, Shanghai, China.
2
Department of Gastroenterology, Huadong Hospital Affiliated to Fudan University, Shanghai, China.
3
Department of Gastroenterology, Huadong Hospital Affiliated to Fudan University, Shanghai, China jiechencn@yeah.net.
4
Department of Rehabilitation Medicine, Huadong Hospital Affiliated to Fudan University, Shanghai, China.
5
Department of Nuclear Medicine, Huadong Hospital Affiliated to Fudan University, Shanghai, China.

Abstract

The relationship between gastric emptying dysfunction and blood glucose concentration in elderly with type 2 diabetes mellitus was investigated, and the effect of rehabilitation exercise prescription training on gastric emptying in the geriatric diabetic patients was evaluated. A total of 160 older type 2 diabetic adults and 30 cases of non-diabetic patients were studied with regard to the gastric half emptying time (GET1/2) of solid meals radiolabelled with 99mTc. Eighty delayed gastric emptying diabetic patients were randomly divided into 4 four groups: rehabilitation exercise + mosapride group (N = 20), rehabilitation exercise group (N = 20), mosapride group (N = 20), and control group (N = 20). The level of blood glucose was measured every six months in a two-year follow-up. The solid GET1/2 of regulated blood glycemic control patients showed no statistically significant differences from non-diabetic patients (P > 0.05). However, the value for poor blood glycemic control patients exhibited significant statistical differences compared with both non-diabetic (P < 0.01) and regulated blood glycemic control group patients (P < 0.01). It showed that the gastric emptying time improved in the rehabilitation exercise group, mosapride group and rehabilitation exercise group + mosapride group after two years of treatment (P < 0.05). Fasting blood glucose in both rehabilitation exercise group and rehabilitation exercise + mosapride group was significantly decreased. Postprandial blood glucose in the rehabilitation exercise group, mosapride group, rehabilitation exercise group + mosapride group was significantly decreased. High blood glucose level can delay gastric emptying in older type 2 diabetic patients. Gastric emptying and blood glucose control affect each other. It was shown that appropriate rehabilitation exercise combined with prokinetic agent may improve gastric emptying in some geriatric type 2 diabetic patients and help control their blood glucose.

PMID:
24615075
DOI:
10.4238/2014.January.24.5
[Indexed for MEDLINE]
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