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Immunol Res. 2014 May;58(2-3):186-92. doi: 10.1007/s12026-014-8495-2.

Tissue integrity signals communicated by high-molecular weight hyaluronan and the resolution of inflammation.

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1
Division of Infectious Diseases, Stanford University School of Medicine, 300 Pasteur Drive, Rm. L-133, Stanford, CA, 94305-5107, USA.

Abstract

The extracellular matrix polysaccharide hyaluronan (HA) exerts size-dependent effects on leukocyte behavior. Low-molecular weight HA is abundant at sites of active tissue catabolism and promotes inflammation via effects on Toll-like receptor signaling. Conversely, high-molecular weight HA is prevalent in uninjured tissues and is anti-inflammatory. We propose that the ability of high-molecular weight but not low-molecular weight HA to cross-link CD44 functions as a novel form of pattern recognition that recognizes intact tissues and communicates "tissue integrity signals" that promote resolution of local immune responses.

PMID:
24614953
PMCID:
PMC4106675
DOI:
10.1007/s12026-014-8495-2
[Indexed for MEDLINE]
Free PMC Article
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