Format

Send to

Choose Destination
Implant Dent. 2014 Apr;23(2):132-7. doi: 10.1097/ID.0000000000000035.

De novo bone regeneration in human extraction sites using recombinant human bone morphogenetic protein-2/ACS: a clinical, histomorphometric, densitometric, and 3-dimensional cone-beam computerized tomographic scan evaluation.

Author information

1
*Private Practice, Periodontics, Wilmington, NC. †Private Practice, Oral Maxillofacial Surgery, Palm Harbor, FL; Director, Pikos Implant Institute, Spring Hill, FL. ‡Senior Research Scientist, Hard Tissue Research Laboratory, University of Minnesota School of Dentistry, Minneapolis, MN.

Abstract

INTRODUCTION:

To preserve alveolar bone after extractions, it is important to graft socket sites to prevent bone loss from repair and remodeling.

OBJECTIVE:

The objective of this case series was to assess the clinical, densitometric, and histomorphometric results from extraction sockets treated with recombinant human bone morphogenetic protein (rhBMP-2/ACS).

STUDY DESIGN:

After extraction and socket debridement, INFUSE (rhBMP-2) on absorbable sponges was placed over each socket. After 4 months, 3-dimensional cone-beam computerized tomographic (CT) scans were taken. Trephined bone cores were taken as the first step in the implant site osteotomy and submitted for histomorphometric analysis.

RESULTS:

Histomorphometric analysis showed a mean of 49.6% vital bone with a SD of 10.8%. CT scans showed mean density of 510.6 Hounsfield units.

CONCLUSIONS:

Use of INFUSE in socket preservation surgery results in adequate de novo bone formation to support ideal implant placement after 4 months.

PMID:
24614876
DOI:
10.1097/ID.0000000000000035
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Wolters Kluwer
Loading ...
Support Center