Format

Send to

Choose Destination
Fungal Genet Biol. 2014 May;66:79-85. doi: 10.1016/j.fgb.2014.02.009. Epub 2014 Mar 12.

The protein phosphatase PhzA of A. fumigatus is involved in oxidative stress tolerance and fungal virulence.

Author information

1
Unité des Aspergillus, Institut Pasteur, 25 rue du Docteur Roux, 75724 Paris Cedex 15, France. Electronic address: llaetitia.muszkieta@pasteur.fr.
2
Department of Ophthalmology and Visual Sciences, Case Western Reserve University, Cleveland, OH 44106, USA.
3
Université Pierre et Marie Curie-Paris 6, INSERM UMR-S 945, Immunité et Infection, Hôpital Pitié Salpêtrière, Paris, France.
4
Unité des Aspergillus, Institut Pasteur, 25 rue du Docteur Roux, 75724 Paris Cedex 15, France.

Abstract

Protein phosphatases Z that are unique to the fungal kingdom have been associated to resistance to high salt concentration, cell wall integrity, cell cycle regulation, and oxidative stress in fungi. In Aspergillus fumigatus, it was shown that PHZA is under the control of the transcription factor Skn7 and is only involved in the control of the oxidative stress. Accordingly, the ΔphzA mutant showed a defect in virulence in an experimental model of corneal infection in immunocompetent animals and that the impact on susceptibility to cell wall drugs is only secondary.

KEYWORDS:

Aspergillus fumigatus; Corneal infection; Oxidative stress; Phosphatase; Virulence

PMID:
24614084
PMCID:
PMC4503245
DOI:
10.1016/j.fgb.2014.02.009
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Elsevier Science Icon for PubMed Central
Loading ...
Support Center