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Fungal Genet Biol. 2014 May;66:11-8. doi: 10.1016/j.fgb.2014.02.008. Epub 2014 Mar 5.

Molecular mechanisms of Aspergillus flavus secondary metabolism and development.

Author information

1
University of Wisconsin - Madison, 3476 Microbial Sciences Building, 1550 Linden Drive, Madison, WI 53706-1521, United States.
2
University of Wisconsin - Madison, 3476 Microbial Sciences Building, 1550 Linden Drive, Madison, WI 53706-1521, United States. Electronic address: npkeller@wisc.edu.

Abstract

The plant and human opportunistic fungus Aspergillus flavus is recognized for the production of the carcinogen aflatoxin. Although many reviews focus on the wealth of information known about aflatoxin biosynthesis, few articles describe other genes and molecules important for A. flavus development or secondary metabolism. Here we compile the most recent work on A. flavus secondary metabolite clusters, environmental response mechanisms (stress response pathways, quorum sensing and G protein signaling pathways) and the function of the transcriptional regulatory unit known as the Velvet Complex. A comparison to other Aspergilli reveals conservation in several pathways affecting fungal development and metabolism.

KEYWORDS:

Aflatoxin; Aspergillus flavus; Gene cluster; LaeA; Quorum; VeA

PMID:
24613992
DOI:
10.1016/j.fgb.2014.02.008
[Indexed for MEDLINE]

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