Send to

Choose Destination
Behav Brain Res. 2014 Jun 1;266:46-51. doi: 10.1016/j.bbr.2014.02.045. Epub 2014 Mar 5.

Embryonic intraventricular exposure to autism-specific maternal autoantibodies produces alterations in autistic-like stereotypical behaviors in offspring mice.

Author information

Department of Pathology and Laboratory Medicine, UC Davis, 95817.
Institute for Pediatric Regenerative Medicine and Shriners Hospitals for Children Northern California, 95817.
M.I.N.D. Institute, UC Davis, 95817.
Department of Rheumatology/Allergy and Clinical Immunology, UC Davis, 95616.
Department of Psychiatry and Behavioral Sciences, UC Davis, 95817.
Contributed equally


Multiple studies have implicated a role of maternal autoantibodies reactive against fetal brain proteins specific to autism in the etiology of autism spectrum disorders (ASD). In the current study, we examined the impact of brain-reactive maternal autoantibodies of mothers of children with autism (MAU) on offspring behavior in mice compared to offspring exposed to non-reactive IgG of mothers of typically developing children (MTD). Embryonic offspring were exposed to a single intraventricular injection of MAU or MTD IgG on embryonic day 14. Offspring were allowed to mature to adulthood and were subsequently tested for sociability and stereotypic behaviors using a 3-chambered social approach task, marble burying task, and assessment of spontaneous grooming behaviors in response to a novel environment. Results indicate that MAU offspring display autistic-like stereotypical behavior in both marble burying and spontaneous grooming behaviors. Additionally, small alterations in social approach behavior were also observed in MAU offspring compared to MTD offspring. This report demonstrates for the first time the effects of a single, low dose intraventricular exposure of IgG derived from individual MAU samples on offspring behavior.


Autism spectrum disorders; Immune; In utero exposure; Maternal antibodies; Mouse behavior

[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Elsevier Science Icon for PubMed Central
Loading ...
Support Center