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Microbes Infect. 2014 May;16(5):429-33. doi: 10.1016/j.micinf.2014.02.003. Epub 2014 Mar 5.

Influence of NleH effector expression, host genetics, and inflammation on Citrobacter rodentium colonization of mice.

Author information

1
Department of Diagnostic Medicine/Pathobiology, College of Veterinary Medicine, Kansas State University, Manhattan, KS 66506, USA.
2
Department of Diagnostic Medicine/Pathobiology, College of Veterinary Medicine, Kansas State University, Manhattan, KS 66506, USA. Electronic address: hardwidg@gmail.com.

Abstract

The Escherichia coli NleH1 and NleH2 virulence proteins differentially regulate host transcription of innate immunity genes. The mouse pathogen Citrobacter rodentium encodes one NleH protein, which functions equivalently to E. coli NleH1. We examined the impact of host genetics and intestinal inflammation on the contribution of NleH to C. rodentium colonization of mice differing in LPS responsiveness. NleH expression was detrimental to C. rodentium in C57BL/10ScNJ mice, which do not mount LPS-induced inflammatory responses. This phenotype was reversed if inflammation was induced by chemical means. C. rodentium that expressed both E. coli NleH1 and NleH2 was hypervirulent in C3H/HeJ mice.

KEYWORDS:

Escherichia coli; Innate immunity; NF-kappa B (NF-κB); NleH1

PMID:
24613200
PMCID:
PMC4040159
DOI:
10.1016/j.micinf.2014.02.003
[Indexed for MEDLINE]
Free PMC Article
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