Association between the ICAM-1 K469E polymorphism and diabetic retinopathy in Type 2 diabetes mellitus: a meta-analysis

Hongyan Sun; Xianling Cong; Ran Sun; Chuanwen Wang; Xue Wang; Ya Liu

doi:10.1016/j.diabres.2014.01.028

Association between the ICAM-1 K469E polymorphism and diabetic retinopathy in Type 2 diabetes mellitus: a meta-analysis

Diabetes Res Clin Pract. 2014 May;104(2):e46-9. doi: 10.1016/j.diabres.2014.01.028. Epub 2014 Feb 10.

Authors

Hongyan Sun¹, Xianling Cong², Ran Sun², Chuanwen Wang³, Xue Wang⁴, Ya Liu⁵

Affiliations

¹ Tissue Bank, China-Japan Union Hospital of Jilin University, Changchun 130033, Jilin Province, China; Nutrition and Food Hygiene department, School of Public Health, Jilin University, Changchun 130021, Jilin Province, China.
² Tissue Bank, China-Japan Union Hospital of Jilin University, Changchun 130033, Jilin Province, China.
³ Radiological Health Department, Occupation Disease Prevention and Control Center of Jilin Province, Changchun 130061, Jilin Province, China.
⁴ Medical Examination Center, China-Japan Union Hospital of Jilin University, Changchun 130033, Jilin Province, China.
⁵ Nutrition and Food Hygiene department, School of Public Health, Jilin University, Changchun 130021, Jilin Province, China. Electronic address: liuyajlu@163.com.

PMID: 24612665
DOI: 10.1016/j.diabres.2014.01.028

Abstract

A meta-analysis was conducted to evaluate the association of ICAM-1 K469E gene polymorphism with diabetic retinopathy susceptibility in Type 2 diabetes mellitus. Seven studies involving 1094 cases and 909 controls were included. Current studies suggest that K469E polymorphism in ICAM-1 gene might not affect individual susceptibility to DR.

Keywords: Diabetic retinopathy; ICAM-1 polymorphism; Meta-analysis; Type 2 diabetes mellitus.

Publication types

Meta-Analysis
Research Support, Non-U.S. Gov't
Review

MeSH terms

DNA / genetics*
Diabetes Mellitus, Type 2* / complications
Diabetes Mellitus, Type 2* / genetics
Diabetes Mellitus, Type 2* / metabolism
Diabetic Retinopathy* / etiology
Diabetic Retinopathy* / genetics
Diabetic Retinopathy* / metabolism
Genetic Predisposition to Disease*
Humans
Intercellular Adhesion Molecule-1 / genetics*
Intercellular Adhesion Molecule-1 / metabolism
Polymorphism, Genetic*

Substances

Intercellular Adhesion Molecule-1
DNA