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J Vet Intern Med. 2014 Mar-Apr;28(2):496-503. doi: 10.1111/jvim.12319. Epub 2014 Feb 24.

Qualitative and quantitative contrast-enhanced ultrasonographic assessment of cerulein-induced acute pancreatitis in dogs.

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  • 1Laboratory of Veterinary Internal Medicine, Graduate School of Veterinary Medicine, Hokkaido University, Hokkaido, Japan.

Abstract

BACKGROUND:

Acute pancreatitis (AP) is the most common disease of the canine exocrine pancreas, and accurate noninvasive diagnosis is challenging.

HYPOTHESIS/OBJECTIVES:

To determine the feasibility of using quantitative contrast-enhanced ultrasonography (CEUS) to detect pancreatic perfusional changes in cerulein-induced AP in dogs.

ANIMALS:

Six adult female Beagles.

METHODS:

Each dog received 2 hours of IV infusion with 7.5 μg/kg/h of cerulein diluted in saline. As control, all dogs received 2 hours of IV infusion of saline 2 weeks before cerulein infusion. CEUS of the pancreas and duodenum were performed before (0 hour), and at 2, 4, 6, and 12 hours after saline and cerulein infusion. Time-intensity curves were created from regions of interest in the pancreas and duodenum. Five perfusional parameters were measured for statistical analysis: time to initial up-slope, peak time, time to wash-out, peak intensity (PI), and area under the curve (AUC).

RESULTS:

In cerulein-induced AP, pancreatic PI increased at 2 and 4 hours when compared to 0 hour, and at 2, 4, and 6 hours when compared to control. AUC increased at 4 hours when compared to 0 hour, and at 2 and 4 hours when compared to control. Time to wash-out was prolonged at 4 hours when compared to control. For saline control, peak time was faster at 2 hours when compared to 0 hour.

CONCLUSIONS AND CLINICAL IMPORTANCE:

CEUS parameters PI and AUC can provide useful information in differentiating acute pancreatitis from normal pancreas. Cerulein-induced AP was characterized by prolonged hyperechoic enhancement on CEUS.

KEYWORDS:

Contrast-ultrasound; Inflammation; Pancreas; Perfusion

PMID:
24612403
PMCID:
PMC4858020
DOI:
10.1111/jvim.12319
[PubMed - indexed for MEDLINE]
Free PMC Article
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