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J Cardiovasc Electrophysiol. 2014 Jul;25(7):756-62. doi: 10.1111/jce.12391. Epub 2014 Mar 19.

Coupling interval dispersion and body mass index are independent predictors of idiopathic premature ventricular complex-induced cardiomyopathy.

Author information

1
Division of Cardiology, University of California, San Francisco, California, USA.

Abstract

INTRODUCTION:

Patients with frequent premature ventricular complexes (PVCs) might be at risk for the developing or exacerbation of left ventricular (LV) dysfunction. However, some patients with a high-PVC burden do not develop cardiomyopathy, while other patients with low-PVC burden can develop cardiomyopathy. The purpose of this study was to evaluate the positive predictors of idiopathic PVCs-induced cardiomyopathy.

METHODS AND RESULTS:

We investigated 214 patients undergoing successful ablation of PVCs who had no other causes of cardiomyopathy. We divided the study cohort into 2 groups: ejection fraction (EF) ≥ 50% (normal LV) and EF < 50% (LV dysfunction). We analyzed the clinical characteristics, including the electrocardiogram and findings at electrophysiology study. Among these patients, 51 (24%) had reduced LVEF and 163 (76%) had normal LV function. Patients with LV dysfunction had significantly longer coupling interval (CI) dispersion (maximum-CI-minimum-CI) and had significantly higher PVC burden compared to those with normal LV function (CI-dispersion: 115 ± 25 milliseconds vs. 94 ± 19 milliseconds; P < 0.001; PVC burden: 19% vs. 15%; P = 0.04). Furthermore, patients with LV dysfunction had significantly higher body mass index (BMI) compared to those with normal LV function (BMI > 30 kg/m(2) ; 37% vs. 13%; P = 0.001). Logistic regression analysis showed that CI-dispersion, PVC burden, and BMI (>30 kg/m(2) ) are independent predictors of PVC-induced cardiomyopathy.

CONCLUSIONS:

In addition to the PVC burden, the CI-dispersion and BMI are associated with PVC-induced cardiomyopathy.

KEYWORDS:

PVC burden; body mass index; cardiomyopathy; catheter ablation; premature ventricular complexes; ventricular arrhythmia

PMID:
24612052
DOI:
10.1111/jce.12391
[Indexed for MEDLINE]

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