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Psychophysiology. 2014 Jun;51(6):510-9. doi: 10.1111/psyp.12201. Epub 2014 Feb 24.

Modafinil augments oscillatory power in middle frequencies during rule selection.

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Department of Psychiatry, University of California, San Francisco School of Medicine, San Francisco, California, USA; San Francisco Veterans Affairs Medical Center, San Francisco, California, USA.


Control-related cognitive processes are associated with cortical oscillations and modulated by catecholamine neurotransmitters. It remains unclear how catecholamine systems modulate control-related oscillations. We tested modafinil effects on rule-related 4-30 Hz oscillations, with double-blind, placebo-controlled (within-subjects) testing of 22 healthy adults, using EEG during cognitive control task performance. EEG data underwent time-frequency decomposition with Morlet wavelets to determine power of 4-30 Hz oscillations. Modafinil enhanced oscillatory power associated with high-control rule selection in theta, alpha, and beta ranges, with a frontotemporal topography and minimal effects during rule maintenance. Augmentation of catecholamine signaling enhances middle-frequency cortical oscillatory power associated with rule selection, which may subserve diverse subcomponent processes in proactive cognitive control.


Cognitive control; Modafinil; Oscillations; Prefrontal cortex; Rule selection; Theta

[Indexed for MEDLINE]

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