Format

Send to

Choose Destination
See comment in PubMed Commons below
Nat Rev Microbiol. 2014 Apr;12(4):274-88. doi: 10.1038/nrmicro3235. Epub 2014 Mar 10.

Bordetella pertussis pathogenesis: current and future challenges.

Author information

1
Department of Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599-7290, USA.
2
Department of Microbiology, Immunology & Molecular Genetics, University of California, Los Angeles, California 90095-1489, USA.

Abstract

Pertussis, also known as whooping cough, has recently re-emerged as a major public health threat despite high levels of vaccination against the aetiological agent Bordetella pertussis. In this Review, we describe the pathogenesis of this disease, with a focus on recent mechanistic insights into B. pertussis virulence-factor function. We also discuss the changing epidemiology of pertussis and the challenges facing vaccine development. Despite decades of research, many aspects of B. pertussis physiology and pathogenesis remain poorly understood. We highlight knowledge gaps that must be addressed to develop improved vaccines and therapeutic strategies.

PMID:
24608338
PMCID:
PMC4205565
DOI:
10.1038/nrmicro3235
[Indexed for MEDLINE]
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Nature Publishing Group Icon for PubMed Central
    Loading ...
    Support Center