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Curr Opin Neurobiol. 2014 Aug;27:31-8. doi: 10.1016/j.conb.2014.02.012. Epub 2014 Mar 6.

Myelin-associated inhibitors in axonal growth after CNS injury.

Author information

1
Department of Neurosciences, University of California at San Diego, La Jolla, CA, USA.
2
Department of Neurosciences, University of California at San Diego, La Jolla, CA, USA. Electronic address: binhai@ucsd.edu.

Abstract

There are multiple barriers to axonal growth after CNS injury. Myelin-associated inhibitors represent one group of barriers extrinsic to the injured neurons. Nogo, MAG and OMgp are three prototypical myelin inhibitors that signal through multiple neuronal receptors to exert growth inhibition. Targeting myelin inhibition alone modulates the compensatory sprouting of uninjured axons but the effect on the regeneration of injured axons is limited. Meanwhile, modulating sprouting, a naturally occurring repair mechanism, may be a more attainable therapeutic goal for promoting functional repair after CNS injury in the near term.

PMID:
24608164
PMCID:
PMC4122599
DOI:
10.1016/j.conb.2014.02.012
[Indexed for MEDLINE]
Free PMC Article

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