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Curr Opin Neurobiol. 2014 Aug;27:16-24. doi: 10.1016/j.conb.2014.02.006. Epub 2014 Mar 7.

Ephrin signalling in the developing nervous system.

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Department of Molecules - Signaling - Development, Max Planck Institute of Neurobiology, Am Klopferspitz 18, 82152 Martinsried, Germany; Munich Cluster for Systems Neurology (Synergy), Munich, Germany. Electronic address:
Institut de Recherches Cliniques de Montréal (IRCM), Montréal, QC, Canada H2W 1R7; Département de Médecine, Université de Montréal, Montréal, QC, Canada H3T 1J4; Division of Experimental Medicine, Departments of Biology, and, Anatomy and Cell Biology and Integrated Program in Neurosciences, McGill University, Montréal, QC, Canada H3A 1A3. Electronic address:


Ephrin ligands and their Eph receptors hold our attention since their link to axon guidance almost twenty years ago. Since then, they have been shown to be critical for short distance cell-cell interactions in the nervous system. The interest in their function has not abated, leading to ever-more sophisticated studies generating as many surprising answers about their function as new questions. We discuss recent insights into their functions in the developing nervous system, including neuronal progenitor sorting, stochastic cell migration, guidance of neuronal growth cones, topographic map formation, as well as synaptic plasticity.

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