Format

Send to

Choose Destination
See comment in PubMed Commons below
Nutrition. 2014 Apr;30(4):424-9. doi: 10.1016/j.nut.2013.09.009.

The protein type within a hypocaloric diet affects obesity-related inflammation: the RESMENA project.

Author information

1
Department of Nutrition, Food Science and Physiology, University of Navarra, Pamplona, Spain.
2
Biodonostia Health Research Institute, San Sebastian, Spain; CIBERobn, Carlos III Health Institute, Madrid, Spain.
3
Department of Nutrition, Food Science and Physiology, University of Navarra, Pamplona, Spain; CIBERobn, Carlos III Health Institute, Madrid, Spain.
4
Department of Nutrition, Food Science and Physiology, University of Navarra, Pamplona, Spain; CIBERobn, Carlos III Health Institute, Madrid, Spain. Electronic address: jalfmtz@unav.es.

Abstract

OBJECTIVES:

The aim of this study was to compare the effect of two energy-restricted, differing with regard to protein content, on the inflammation state of obese individuals with features of metabolic syndrome.

METHODS:

Ninety-six participants completed an 8-wk randomized intervention trial that compared the RESMENA diet (-30% energy, with 30% energy from protein) with a control diet (-30% energy, with 15% energy from protein) that was based on American Heart Association criteria.

RESULTS:

The mean body weight losses were 7.09 ± 0.82 kg and 6.73 ± 0.71 kg, respectively, with no differences seen between the groups. The endpoint inflammation score-which was based on high-sensitivity C-reactive protein, interleukin-6, tumor necrosis factor-α, and plasminogen activator inhibitor-1 levels-was significantly lower (P = 0.012) in the low-protein group (6.81 ± 2.32 versus 7.94 ± 1.94). The linear regression analyses revealed that total protein intake was positively associated with inflammation (P = 0.007) as well as with animal protein (P = 0.025) and meat protein (P = 0.015), but neither vegetable- nor fish-derived proteins were found to influence inflammatory status.

CONCLUSIONS:

Our results suggest that the type of protein consumed (more than the total protein consumed) within an energy-restricted diet influences the inflammation status associated with obesity-related comorbidities.

KEYWORDS:

Cardiovascular diseases; Inflammation markers; Macronutrient distribution; Metabolic syndrome; Weight loss

PMID:
24607301
DOI:
10.1016/j.nut.2013.09.009
[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Support Center