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Cell Metab. 2014 Mar 4;19(3):354-6. doi: 10.1016/j.cmet.2014.02.014.

Independent control of aging and axon regeneration.

Author information

1
F.M. Kirby Neurobiology Center, Children's Hospital, and Department of Neurology, Harvard Medical School, Boston, MA 02115, USA.
2
F.M. Kirby Neurobiology Center, Children's Hospital, and Department of Neurology, Harvard Medical School, Boston, MA 02115, USA. Electronic address: zhigang.he@childrens.harvard.edu.

Abstract

Axon regeneration capacity often declines with age. One might assume that loss of regeneration is an obvious consequence of organismal aging. However, in the latest issue of Neuron, Byrne et al. (2014) demonstrate that regeneration ability and aging are regulated cell-autonomously within neurons, and can be decoupled.

PMID:
24606896
PMCID:
PMC4049281
DOI:
10.1016/j.cmet.2014.02.014
[Indexed for MEDLINE]
Free PMC Article

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