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Bonekey Rep. 2014 Feb 5;3:498. doi: 10.1038/bonekey.2013.232. eCollection 2014.

Vitamin D and chronic kidney disease-mineral bone disease (CKD-MBD).

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Division of Nephrology, Massachusetts General Hospital , Boston, MA, USA.
Division of Cardiology, Beth Israel Deaconess Medical Center , Boston, MA, USA.


Chronic kidney disease (CKD) is a modern day epidemic and has significant morbidity and mortality implications. Mineral and bone disorders are common in CKD and are now collectively referred to as CKD- mineral and bone disorder (MBD). These abnormalities begin to appear even in early stages of CKD and contribute to the pathogenesis of renal osteodystrophy. Alteration in vitamin D metabolism is one of the key features of CKD-MBD that has major clinical and research implications. This review focuses on biology, epidemiology and management aspects of these alterations in vitamin D metabolism as they relate to skeletal aspects of CKD-MBD in adult humans.

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