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Dermatology. 2014;228(3):225-32. doi: 10.1159/000357764. Epub 2014 Feb 28.

Oral terbinafine and itraconazole treatments against dermatophytes appear not to favor the establishment of Fusarium spp. in nail.

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1
Department of Dermatology, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland.

Abstract

BACKGROUND:

Fusarium onychomycoses are weakly responsive or unresponsive to standard onychomycosis treatments with oral terbinafine and itraconazole.

OBJECTIVE:

To examine whether the use of terbinafine and itraconazole, which are highly effective in fighting Trichophyton onychomycoses, could be a cause of the high incidence of Fusarium nail infections.

METHODS:

Polymerase chain reaction methods were used to detect both Fusarium spp. and Trichophyton spp. in nails of patients who had either received treatment previously or not.

RESULTS:

No significant microbiological differences were found between treated and untreated patients. In 24 of 79 cases (30%), Fusarium spp. was detected in samples of patients having had no previous antifungal therapy and when Trichophyton spp. grew in culture.

CONCLUSION:

Oral terbinafine and itraconazole treatments do not appear to favor the establishment of Fusarium spp. in onychomycosis.

PMID:
24603371
DOI:
10.1159/000357764
[Indexed for MEDLINE]

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