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Eur J Radiol. 2014 May;83(5):773-7. doi: 10.1016/j.ejrad.2014.01.021. Epub 2014 Feb 6.

Added value of Virtual Touch IQ shear wave elastography in the ultrasound assessment of breast lesions.

Author information

1
Radiology Department, Gustave Roussy, Villejuif, France.
2
Department of Statistics, Gustave Roussy, Villejuif, France.
3
Department of Biopathology, Gustave Roussy, Villejuif, France.
4
Department of Surgery, Gustave Roussy, Villejuif, France.
5
Department of Oncology, Gustave Roussy, Villejuif, France.
6
Department of Surgery, Bucharest Institute of Oncology, Bucharest, Romania.
7
Radiology Department, Gustave Roussy, Villejuif, France; UMR 8081, IR4M, Paris-Sud University, 91405 Orsay, France. Electronic address: corinne.balleyguier@gustaveroussy.fr.

Abstract

PURPOSE:

To determine the diagnostic performance of Acoustic Radiation Force Impulse (ARFI) Virtual Touch IQ shear wave elastography in the discrimination of benign and malignant breast lesions.

MATERIALS AND METHODS:

Conventional B-mode and elasticity imaging were used to evaluate 110 breast lesions. Elastographic assessment of breast tissue abnormalities was done using a shear wave based technique, Virtual Touch IQ (VTIQ), implemented on a Siemens Acuson S3000 ultrasound machine. Tissue mechanical properties were interpreted as two-dimensional qualitative and quantitative colour maps displaying relative shear wave velocity. Wave speed measurements in m/s were possible at operator defined regions of interest. The pathologic diagnosis was established on samples obtained by ultrasound guided core biopsy or fine needle aspiration.

RESULTS:

BIRADS based B-mode evaluation of the 48 benign and 62 malignant lesions achieved 92% sensitivity and 62.5% specificity. Subsequently performed VTIQ elastography relying on visual interpretation of the colour overlay displaying relative shear wave velocities managed similar standalone diagnostic performance with 92% sensitivity and 64.6% specificity. Lesion and surrounding tissue shear wave speed values were calculated and a significant difference was found between the benign and malignant populations (Mann-Whitney U test, p<0.0001). By selecting a lesion cut-off value of 3.31m/s we achieved 80.4% sensitivity and 73% specificity. Applying this threshold only to BIRADS 4a masses, we reached overall levels of 92% sensitivity and 72.9% specificity.

CONCLUSION:

VTIQ qualitative and quantitative elastography has the potential to further characterise B-mode detected breast lesions, increasing specificity and reducing the number of unnecessary biopsies.

KEYWORDS:

BIRADS 4a; Breast cancer; Elastography; Shear wave; Ultrasound; Virtual Touch IQ

PMID:
24602803
DOI:
10.1016/j.ejrad.2014.01.021
[Indexed for MEDLINE]
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