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Fertil Steril. 2014 May;101(5):1326-30. doi: 10.1016/j.fertnstert.2014.01.055. Epub 2014 Mar 3.

Effect of oocyte donation on pregnancy outcomes in in vitro fertilization twin gestations.

Author information

1
Department of Obstetrics, Gynecology, and Reproductive Science, Icahn School of Medicine at Mount Sinai, New York, New York.
2
Weill-Cornell Medical College, New York, New York.
3
Department of Obstetrics, Gynecology, and Reproductive Science, Icahn School of Medicine at Mount Sinai, New York, New York; Maternal Fetal Medicine Associates, PLLC, New York, New York.
4
Department of Obstetrics, Gynecology, and Reproductive Science, Icahn School of Medicine at Mount Sinai, New York, New York; Maternal Fetal Medicine Associates, PLLC, New York, New York. Electronic address: nfox@mfmnyc.com.

Abstract

OBJECTIVE:

To estimate the effect of oocyte donation on pregnancy outcomes in patients with twin pregnancies conceived via IVF.

DESIGN:

Retrospective cohort study.

SETTING:

Patients with IVF twin pregnancies delivered by one maternal-fetal medicine practice from 2005 to 2013.

PATIENT(S):

Fifty-six patients with IVF twin pregnancies who had oocyte donation and 56 age-matched controls with IVF twin pregnancies who used autologous oocytes. We excluded women aged >50 years because there were no age-matched controls aged >50 years using autologous oocytes.

INTERVENTION(S):

None.

MAIN OUTCOME MEASURE(S):

Gestational hypertension, pre-eclampsia.

RESULT(S):

The baseline characteristics were similar between the groups, including maternal age, race, parity, chorionicity, and comorbidities. The mean (±SD) age was 43.0 ± 6.0 vs. 41.9 ± 1.7 years. There were no differences in outcomes between the groups in regard to preterm birth, birth weight, or gestational diabetes. There was a greater incidence of gestational hypertension (32.1% vs. 13.0%) and pre-eclampsia (28.3% vs. 13.0%) in the group that underwent IVF with donor oocytes.

CONCLUSION(S):

In patients who conceive twin pregnancies using IVF, oocyte donation increases the risk of gestational hypertension and pre-eclampsia. However, this did not translate into increased rates of preterm birth or low birth weight. Patients who require oocyte donation should be carefully counseled regarding the increased risk for pre-eclampsia and gestational hypertension but should be reassured that oocyte donation does not seem to lead to other adverse outcomes.

KEYWORDS:

IVF; Twins; hypertension; oocyte donor

[Indexed for MEDLINE]

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