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Biochem Biophys Res Commun. 1988 Oct 14;156(1):551-6.

Enterotoxin of Clostridium perfringens type A forms ion-permeable channels in a lipid bilayer membrane.

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Research Institute for Microbial Diseases, Osaka University, Japan.


The enterotoxin of Clostridium perfringens type A was found to form ion-permeable channels in a lipid bilayer. A patch clamp technique was used to detect channel activities in an asolectin bilayer with incorporated enterotoxin. About 20% of the lipid bilayer patches examined showed rectangular or stepwise shift of membrane current. The shifts indicated the gating of ion-permeable channels in the patches. The channels showed high conductance (40-450 pS), no rectification in current-voltage curves and occasional long-lasting events. The significance of these findings is discussed in relation to the mechanism of action of the toxin.

[Indexed for MEDLINE]

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