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Saudi J Biol Sci. 2014 Apr;21(2):119-23. doi: 10.1016/j.sjbs.2013.04.004. Epub 2013 Apr 23.

Ganoderma lucidum polysaccharides supplementation attenuates exercise-induced oxidative stress in skeletal muscle of mice.

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Zhejiang Police College, Hangzhou, Zhejiang 310053, PR China.
Department of Physical Education and Military Training, Zhejiang University of Technology, Hangzhou 310014, PR China.
Hangzhou College of Commerce, Zhejiang Gongshang University, Hangzhou, Zhejiang 310012, PR China.


The present study was designed to determine the effects of Ganoderma lucidum polysaccharides (GL-PS) on exhaustive exercise-induced oxidative stress in skeletal muscle tissues of mice. The mice were divided into four groups (three GL-PS administered groups and the control group). The control group was administered with distilled water and GL-PS administered groups were administered with GL-PS (50, 100 and 200 mg/kg body weight per day). After 28 days, the mice performed an exhaustive swimming exercise, along with the determination of superoxide dismutase (SOD), glutathione peroxidase (GPX), catalase (CAT) activities and malondialdehyde (MDA) levels in the skeletal muscle of mice. The results showed that GL-PS could increase antioxidant enzymes activities and decrease the MDA levels in the skeletal muscle of mice. This study provides strong evidence that GL-PS supplementation possessed protective effects against exhaustive exercise-induced oxidative stress.


Exhaustive exercise-induced oxidative; Ganoderma lucidum polysaccharides; Mice; Swimming exercise

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