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Head Neck. 2015 May;37(5):624-9. doi: 10.1002/hed.23642. Epub 2014 Jul 12.

Design of a prognostic score model for nasopharyngeal carcinoma.

Author information

1
Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Guangzhou, People's Republic of China; Department of Gynecologic Oncology, Sun Yat-sen University Cancer Center, Guangzhou, People's Republic of China.

Abstract

BACKGROUND:

The purpose of this analysis was to create a prognostic score model for newly diagnosed nasopharyngeal carcinoma (NPC) which has not been created before.

METHODS:

We retrospectively reviewed the medical records of 419 patients with newly diagnosed, nondisseminated, and biopsy proven NPC.

RESULTS:

Independent prognostic factors included age >45, stage III/IV, antienzyme rate of Epstein-Barr virus DNase-specific neutralizing antibody (AER) >58%, and absolute neutrophil count (ANC) >4.7 × 10(9) /L. Four prognostic groups based on prognostic score model were obtained: low-risk group (total score = 0-2); low-intermediate-risk group (total score = 3-4); high-intermediate-risk group (total score = 5-6); and high-risk group (total score = 7).

CONCLUSION:

Our proposed prognostic score model was a useful tool for improving the prognostic assessment of patients with NPC, stratifying patients into different risk groups that call for different treatments, and comparing clinical trials.

KEYWORDS:

absolute neutrophil count; nasopharyngeal carcinoma; prognostic factors; prognostic score model

PMID:
24599631
DOI:
10.1002/hed.23642
[Indexed for MEDLINE]
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