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Nat Struct Mol Biol. 2014 Mar;21(3):207-8. doi: 10.1038/nsmb.2782.

Gathering around Firre.

Author information

1
RNA Biology Laboratory, RIKEN, Wako, Japan.
2
Chromosome Dynamics Laboratory, RIKEN, Wako, Japan.

Abstract

Long noncoding RNAs (lncRNAs) have divergent roles in the nuclei of higher eukaryotes, including chromatin modification and regulation of nuclear bodies. A new study adds a new lncRNA function to the current list: serving as a platform for trans-chromosomal associations. At least three gene loci located on different chromosomes are brought together around the transcription site of a lncRNA termed functional intergenic repeating RNA element (Firre).

PMID:
24599247
DOI:
10.1038/nsmb.2782
[Indexed for MEDLINE]

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