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J Asian Nat Prod Res. 2014;16(4):418-21. doi: 10.1080/10286020.2014.885506.

A new periplogenin cardenolide from the seeds of Antiaris toxicaria.

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1
a College of Pharmacy, Ningxia Medical University , Yinchuan 750004 , China.

Abstract

A new periplogenin cardenolide, periplogulcoside (1), together with three known cardenolides, was isolated from the seeds of Antiaris toxicaria. The structure of the new compound was characterized as periplogenin-3-O-β-D-glucopyranosyl-(1 → 4)-β-D-glucopyranoside (1) by spectroscopic methods including 1D and 2D NMR, HR-TOF-MS, and CD spectrometry, and the known compounds were identified by comparison of their NMR and HR-TOF-MS data with those reported in the literature. Compound 1 showed significant cytotoxicity against Hela and HepG-2 cell lines.

PMID:
24597720
DOI:
10.1080/10286020.2014.885506
[Indexed for MEDLINE]
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