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Biomol Ther (Seoul). 2014 Jan;22(1):73-7. doi: 10.4062/biomolther.2013.094.

Enhanced In Vitro Skin Deposition Properties of Retinyl Palmitate through Its Stabilization by Pectin.

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College of Pharmacy, Chung-Ang University, Seoul 156-756.
Department of Pharmaceutics and Biotechnology, Medical Engineering College, Konyang University, Nonsan 320-711.
Department of Food Science and Technology, Chung-Ang University, Anseong 456-756.
Department of Food Science and Biotechnology, Dongnam Health College, Suwon 440-714, Republic of Korea.


The purpose of this study was to examine the effect of stabilization of retinyl palmitate (RP) on its skin permeation and distribution profiles. Skin permeation and distribution study were performed using Franz diffusion cells along with rat dorsal skin, and the effect of drug concentration and the addition of pectin on skin deposition profiles of RP was observed. The skin distribution of RP increased in a concentration dependent manner and the formulations containing 0.5 and 1 mg of pectin demonstrated significantly increased RP distributions in the epidermis. Furthermore, it was found that skin distribution of RP could be further improved by combined use of pectin and ascorbyl palmitate (AP), due largely to their anti-oxidative effect. These results clearly demonstrate that the skin deposition properties of RP can be improved by stabilizing RP with pectin. Therefore, it is strongly suggested that pectin could be used in the pharmaceutical and cosmetic formulations as an efficient stabilizing agent and as skin penetration modulator.


Anti-oxidative effect; Pectin; Retinyl palmitate; Skin deposition; Stabilization

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