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Anticancer Res. 2014 Mar;34(3):1401-7.

Kiss-1/GPR54 protein expression in breast cancer.

Author information

1
Department of Physiology, Medical School, National & Kapodistrian University of Athens, 75 Micras Asias, Goudi, Athens, 115 27, Greece. mkoutsil@med.uoa.gr.

Abstract

BACKGROUND:

Numerous studies have shown that the Kiss-1 gene countervails the metastatic aptitude of several cancer cell lines and solid-tumor neoplasias. However, there still remains ambiguity regarding its role in breast cancer and literature has arisen asserting that Kiss-1 expression may be linked to an aggressive phenotype and malignant progression. Herein, we investigated the protein expression of Kiss-1 and its receptor GPR54 in breast cancer tissues compared to non-cancerous mammary tissues.

MATERIALS AND METHODS:

Paraffin-fixed cancer tissues from 43 women with resected breast adenocarcinomas and 11 specimens derived from women suffering from fibrocystic disease, serving as controls, were immunostained with Kiss-1 and GPR54 antibodies.

RESULTS:

Kiss-1 and GPR54 protein expression levels were significantly higher in breast cancer compared to fibrocystic tissues (p<0.05). No significant correlation was established between Kiss-1 or GRP54 expression and tumor grade, tumor size, lymph node positivity, histological type or ER status. Kiss-1 expression significantly and positively correlated with GPR54 expression in both breast cancer and fibrocystic disease specimens.

CONCLUSION:

Kiss-1/GPR54 expression was found to be significantly higher in breast cancer compared to non-malignant mammary tissues.

KEYWORDS:

AXOR12; GPCRs; GPR54; Kiss-1; breast cancer

PMID:
24596387
[Indexed for MEDLINE]

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