Send to

Choose Destination
See comment in PubMed Commons below
Angew Chem Int Ed Engl. 2014 Jun 10;53(24):6075-9. doi: 10.1002/anie.201400653. Epub 2014 Mar 5.

Cytoskeletal actin dynamics are involved in pitch-dependent neurite outgrowth on bead monolayers.

Author information

Center for Cell-Encapsulation Research, Department of Chemistry, KAIST, Daejeon 305-701 (Korea); Department of Bio and Brain Engineering, KAIST, Daejeon 305-701 (Korea)


Neurite outgrowth is an important preceding step for the development of nerve systems. Given that the in vivo environments of neurons consist of numerous hierarchical micro/nanotopographies, there have been many efforts to investigate the relationship between neuronal behaviors and surface topography. The acceleration of neurite outgrowth was recently reported on surfaces with a periodic nanotopography, but the biological mechanism has not yet been elucidated. In this work, the initial neurite development of hippocampal neurons on assembled silica beads with diameters ranging from 700 to 1800 nm was explored. The acceleration of neurite outgrowth increased with the surface-pitch size and leveled off after a pitch of 1 μm. Biochemical analysis indicated that cytoskeletal actin dynamics were primarily responsible for the recognition of surface topography. This work contributes to the emerging research field of topographical neurochemistry, as well as applied fields including neuroregeneration and neuroprosthetics.


axon outgrowth; cytoskeletal proteins; nanostructures; neurochemistry; silica beads

PubMed Commons home

PubMed Commons

How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Wiley
    Loading ...
    Support Center