Format

Send to

Choose Destination
Development. 2014 Mar;141(6):1381-91. doi: 10.1242/dev.093435.

Wnt-regulated dynamics of positional information in zebrafish somitogenesis.

Author information

1
Max Planck Institute of Molecular Cell Biology and Genetics, Pfotenhauerstrasse 108, D-01307 Dresden, Germany.

Abstract

How signaling gradients supply positional information in a field of moving cells is an unsolved question in patterning and morphogenesis. Here, we ask how a Wnt signaling gradient regulates the dynamics of a wavefront of cellular change in a flow of cells during somitogenesis. Using time-controlled perturbations of Wnt signaling in the zebrafish embryo, we changed segment length without altering the rate of somite formation or embryonic elongation. This result implies specific Wnt regulation of the wavefront velocity. The observed Wnt signaling gradient dynamics and timing of downstream events support a model for wavefront regulation in which cell flow plays a dominant role in transporting positional information.

KEYWORDS:

Embryonic elongation; Fgf signaling; Segmentation clock; Signal gradient; Time-lapse microscopy; Wnt signaling

PMID:
24595291
PMCID:
PMC3943186
DOI:
10.1242/dev.093435
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for HighWire Icon for PubMed Central
Loading ...
Support Center