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Cancer Biomark. 2013 Jan 1;13(6):411-5. doi: 10.3233/CBM-140390.

Heterogeneous nuclear ribonucleoprotein U-like 1 and Poly (ADP-ribose) polymerase 1 are downregulated in renal cell carcinoma and connected with the prognosis.

Author information

1
Department of Urologic Surgery, The affiliated Cancer Hospital of Jiangsu Province of Nanjing Medical University, Nanjing, Jiangsu, China Department of Urology, First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, China.
2
Department of Urologic Surgery, The affiliated Cancer Hospital of Jiangsu Province of Nanjing Medical University, Nanjing, Jiangsu, China.
3
Department of Urology, First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, China.

Abstract

OBJECTIVE:

To examine the expression of heterogeneous nuclear ribonucleoprotein U-like 1 (hnRPUL1) and poly (ADP-ribose) polymerase 1 (PARP-1) in renal cell carcinoma (RCC) tissues and the connection between the expressions and prognosis of RCC.

MATERIAL AND METHODS:

Total RNAs were extracted from 36 pairs of RCC and their adjacent non-tumor tissues and real-time qRT-PCR was performed.

RESULTS:

The expression of hnRPUL1 was remarkably downregulation in RCC tissues (14/36, 38.9%), compared with matched adjacent non-tumor tissues. And the expression of PARP1 was also remarkably downregulation in RCC tissues (12/36, 30.0%). In the stratification of clinical stage, downregulation in hnRPUL1 and PARP1 were both connected with the advanced clinical stage (P=0.013 and P=0.009). In addition, significantly increased risk of developing with a moderately and poorly differentiated tumor nuclear grade was found in the downregulation of hnRPUL1 patients (P=0.027).

CONCLUSIONS:

Despite the limitations, hnRPUL1 and PARP1 were downregulated in renal cell carcinoma and connected with the prognosis.

KEYWORDS:

Heterogeneous nuclear ribonucleoprotein U-like 1; Poly (ADP-ribose) polymerase 1; renal cell carcinoma

PMID:
24595077
DOI:
10.3233/CBM-140390
[Indexed for MEDLINE]
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