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J Acquir Immune Defic Syndr. 2014 May 1;66(1):1-6. doi: 10.1097/QAI.0000000000000136.

Single-arm evaluation of the AccuCirc device for early infant male circumcision in Botswana.

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*Division of Infectious Diseases, Department of Medicine, Brigham and Women's Hospital, Boston, MA; †Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, MA; ‡Botswana-Harvard School of Public Health AIDS Initiative Partnership for HIV Research and Education, Gaborone, Botswana; §Department of Epidemiology, Harvard School of Public Health, Boston, MA; ‖Northern Inter-Tribal Health Authority, Prince Albert, Saskatchewan, Canada; ¶Botswana Ministry of Health, Gaborne, Botswana; #Departments of Internal Medicine and Pediatrics, Massachusetts General Hospital, Boston, MA; and; **Division of Infectious Diseases, Beth Israel Deaconess Medical Center, Boston, MA.


: Existing devices for early infant male circumcision (EIMC) have inherent limitations. We evaluated the newly developed AccuCirc device by circumcising 151 clinically well, full-term male infants with birth weight ≥2.5 kg within the first 10 days of life from a convenience sample in 2 hospitals in Botswana. No major adverse events were observed. There was 1 local infection, 5 cases of minor bleeding, and 1 case of moderate bleeding. In 3 cases, the device made only partial incisions that were completed immediately by the provider without complications. Parental satisfaction was high: >96% of mothers stated that they would circumcise a future son. The pre-assembled, sterile AccuCirc kit has the potential to overcome obstacles related to supply chain management and on-site instrument disinfection that can pose challenges in resource-limited settings. In our study, the AccuCirc was safe and it should be considered for programmatic EIMC in resource-limited settings.

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