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Trends Mol Med. 2014 May;20(5):271-81. doi: 10.1016/j.molmed.2013.12.001. Epub 2014 Mar 1.

Nanomedicine-based strategies for treatment of atherosclerosis.

Author information

1
Institute for Cardiovascular Prevention (IPEK), LMU Munich, 80336 Munich, Germany; Department of Radiation Oncology, LMU Munich, 81377 Munich, Germany.
2
Department of Internal Medicine III, LMU Munich, 81377 Munich, Germany.
3
Institute for Cardiovascular Prevention (IPEK), LMU Munich, 80336 Munich, Germany.
4
Institute for Cardiovascular Prevention (IPEK), LMU Munich, 80336 Munich, Germany; DZHK (German Centre for Cardiovascular Research), partner site Munich Heart Alliance, 80336 Munich, Germany.
5
Department of Radiation Oncology, LMU Munich, 81377 Munich, Germany.
6
Institute for Cardiovascular Prevention (IPEK), LMU Munich, 80336 Munich, Germany; Department of Pathology, Academic Medical Center (AMC), 1105 AZ Amsterdam, The Netherlands; DZHK (German Centre for Cardiovascular Research), partner site Munich Heart Alliance, 80336 Munich, Germany. Electronic address: oliver.soehnlein@gmail.com.

Abstract

Atherosclerosis is a chronic inflammatory disease of the arterial wall that arises from an imbalanced lipid metabolism and a maladaptive inflammatory response. Despite intensive research on mechanisms underlying atherosclerotic lesion formation and progression during the past decade, translation of this knowledge into the clinic is scarce. Although developments have primarily been made in the area of antitumor therapy, recent advances have shown the potential of nanomedicine-based treatment strategies for atherosclerosis. Here we describe the features of currently available nanomedical formulations that have been optimized for atherosclerosis treatment, and we further describe how they can be instructed to target inflammatory processes in the arterial wall. Despite their limitations, nanomedical applications might hold promise for personalized medicine, and further efforts are needed to improve atherosclerosis-specific targeting.

KEYWORDS:

atherosclerosis; inflammation; liposome; nanomedicine

PMID:
24594264
DOI:
10.1016/j.molmed.2013.12.001
[Indexed for MEDLINE]

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