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Eur J Obstet Gynecol Reprod Biol. 2014 Apr;175:191-3. doi: 10.1016/j.ejogrb.2013.12.023. Epub 2013 Dec 25.

Ultra-short term clomiphene citrate in high responder women with polycystic ovary syndrome: a case series.

Author information

1
Eagen Maternity and Gynaecology Education and Research Hospital, Izmir, Turkey; Izmir Katip Celebi University, School of Medicine, Department of Obstetrics and Gynaecology, Izmir, Turkey. Electronic address: sefakelekci@gmail.com.
2
Izmir Katip Celebi University, School of Medicine, Department of Obstetrics and Gynaecology, Izmir, Turkey. Electronic address: serenateris@Hotmail.Com.
3
Izmir Katip Celebi University, School of Medicine, Department of Obstetrics and Gynaecology, Izmir, Turkey. Electronic address: er_Em.Dr@Hotmail.Com.

Abstract

OBJECTIVE:

To evaluate a new trial of short-term clomiphene citrate (CC) in high responder women with polycystic ovary syndrome (PCOS).

STUDY DESIGN:

This case series was conducted in the infertility outpatient clinics of two centres. Ovulation induction was performed with CC 50-100mg a day in six high-responder women with PCOS who had a history of cancellation of treatment because of ≥3 mature follicles between March 2010 and June 2013. Induction was initiated on the third day of their cycles and the duration of induction was only two days. Demographic data of the patients, number of mature follicles on hCG day, ovulation rate, luteal phase length, pregnancy rate, and type of pregnancy were recorded. All data were analysed by SPSS packet programme (SPSS, 17.0, SPSS Inc., Chicago, IL, USA).

RESULT(S):

The median number of mature follicles and duration of the follicular phase were 1.3 (1-2) and 11.9 (11-14) days, respectively. The ovulation rate was 80% (12/15) and pregnancy rate per cycle was 26.6%.

CONCLUSION(S):

If this hypothesis is supported by large prospective randomised controlled studies, ultra-short term ovulation induction with CC may provide an alternative approach for high-responder women with PCOS who have a history of treatment cycle cancellations.

KEYWORDS:

Clomiphene citrate; Ovulation induction; Ovulation rate; PCOS; Pregnancy rate

PMID:
24594076
DOI:
10.1016/j.ejogrb.2013.12.023
[Indexed for MEDLINE]

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